January 7, 2020

TELOMERE SHORTENING & PREMATURE AGING

A branching process model of telomere shortening A continuous correlation between oxidative stress and telomere shortening in fibroblasts A Critical Role for Pin2/TRF1 in ATM-dependent Regulation […]
January 7, 2020

PREMATURE SENESCENCE

Premature Senescence ”Senescence is more than merely a cell division clock that regulates the proliferative lifespan of normal cells. “Premature” senescence is an active cytostaticprogram that […]
January 7, 2020

JAK INHIBITION ALLEVIATES SASP

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age A hallmark of aging is chronic sterile inflammation, which is closely associated with […]
January 8, 2020

Oncogene Activation

… : VersicanV1 promotes proliferation and metastasis of hepatocellular carcinoma through the activation of EGFR–PI3K–AKT pathway (oncogene,(2018), 37, 41,(5585 … … and functional interaction between polyoma […]
January 10, 2020

JNK PREVENTS PREMATURE SENESCENCE

Prevention of premature senescence requires JNK activation Premature senescence is considered as a cellular defense mechanism to prevent tumorigenesis. Although recent evidences show that c-Jun N-terminal […]
January 10, 2020

MDM2

MDM2 antagonists attenuate the senescence-associated secretory phenotype Processes that have been linked to aging and cancer include an inflammatory milieu driven by senescent cells. Senescent cells […]
January 14, 2020

SENESCENT CELLS, SASP & SENOLYTICS

SHIPPING APRIL 15TH!!! ZOMBIE CELL KILLER   News Articles:  Both Senolytic Molecules Are Inhibitors Of Particular Members Of The Bcl-2 Family Of Apoptosis Regulatory Proteins And […]
January 14, 2020

Andrographis Paniculata

Andrographis Paniculata Hepatoprotective activity of Andrographolide from Andrographis paniculata against carbontetrachloride. Andrographolide protects rat hepatocytes against paracetamol-induced damage In vitro and in vivo anti-inflammatory effects of […]
January 15, 2020

Acorus Gramineu

Alkaloids from Acorus gramineus rhizomes and their biological activity Alpha-asarone, a major component of Acorus gramineus, attenuates corticosterone-induced anxiety-like behaviours via modulating TrkB signaling process Anti-Candida […]